2016, Curr Neurol Neurosci Reports Neuropsychological-effects-of-cerebral-amyloid-angiopathyDownload
Projects
2018, American Journal of Ophthalmology Stroke-and-Stroke-Risk-Factors_authors-preprintDownload
2017, Journal of Neurology PREPRINT-Trends-in-CRAO-management-2017-J-NeurolDownload
2017, Free Radic Biol Med PrePrint-FRBM-Manuscript_Markers-of-oxidative-damage-in-ADDownload
2018, Curr Neurol Neurosci Reports Circulating Troponin Level in Patients with Acute Ischemic Stroke PREPRINTDownload
One of the most complicated issues in clinical AD research is how diet contributes to cognitive decline. There is also unfortunately a great deal of mythology in this area.As a scientist and physician, let me start by saying that we have no evidence that AD can be cured or slowed down by any dietary intervention
One major proposed mechanism to explain changes associated with cellular and organismal aging is that oxidative damage to lipid, protein and nucleic acids accumulates as cells become less capable of coping with oxidative stress. This potentially leads to membrane instability, accumulation of damaged proteins and acquired mutation, all of which may contribute to cellular dysfunctions
We are excited about this developing project and will update this page as we have new results to tell you about. Cerebral amyloid angiopathy is known to cause cerebrovascular fragility, but the specific molecular mechanisms that produce this outcome are not yet fully understood. We discovered in previous work that intense late-complement activation on arterioles
2016, Cerebrovascular Diseases 43(1-2):59-67 Cerebral-Microhemorrhages-and-Meningeal-Siderosis-in-Infective-EndocarditisDownload
Many recent and ongoing clinical trials for the treatment of Alzheimer’s disease are based on the goal of increasing β-amyloid clearance from the brain. A pivotal clinical trial with this approach studied active immunization of patients with AD against β-amyloid and the trial was stopped prematurely when some subjects developed a CNS angiitis. At autopsy,
Cerebral microhemorrhages on susceptibility weight magnetic resonance images are an important biomarker of cerebral arteriopathies. The iron in small foci of bleeding is released from hemoglobin and its magnetic properties induce a focal inhomogeneity in the magnetic field in MR images. This results in a small magnetic dipole artifact in the image which on a