2016, Curr Neurol Neurosci Reports Neuropsychological-effects-of-cerebral-amyloid-angiopathyDownload
Stroke Risk and Risk Factors in Patients with Central Retinal Artery Occlusion
2018, American Journal of Ophthalmology Stroke-and-Stroke-Risk-Factors_authors-preprintDownload
Trends in CRAO management
2017, Journal of Neurology PREPRINT-Trends-in-CRAO-management-2017-J-NeurolDownload
Oxidative markers in AD brain
2017, Free Radic Biol Med PrePrint-FRBM-Manuscript_Markers-of-oxidative-damage-in-ADDownload
Circulating Troponin I Level in Patients with Acute Ischemic Stroke
2018, Curr Neurol Neurosci Reports Circulating Troponin Level in Patients with Acute Ischemic Stroke PREPRINTDownload
Diet and Alzheimer’s
One of the most complicated issues in clinical AD research is how diet contributes to cognitive decline. There is also unfortunately a great deal of mythology in this area.As a scientist and physician, let me start by saying that we have no evidence that AD can be cured or slowed...
Oxidative stress in Alzheimer’s disease and CAA
One major proposed mechanism to explain changes associated with cellular and organismal aging is that oxidative damage to lipid, protein and nucleic acids accumulates as cells become less capable of coping with oxidative stress. This potentially leads to membrane instability, accumulation of damaged proteins and acquired mutation, all of which...
Structural microvascular changes associated with cerebral amyloid angiopathy
We are excited about this developing project and will update this page as we have new results to tell you about. Cerebral amyloid angiopathy is known to cause cerebrovascular fragility, but the specific molecular mechanisms that produce this outcome are not yet fully understood. We discovered in previous work that...
Cerebral Microhemorrhages and Meningeal Siderosis in Infective Endocarditis
2016, Cerebrovascular Diseases 43(1-2):59-67 Cerebral-Microhemorrhages-and-Meningeal-Siderosis-in-Infective-EndocarditisDownload
Lysosome dysfunction in Alzheimer’s disease and CAA
Many recent and ongoing clinical trials for the treatment of Alzheimer’s disease are based on the goal of increasing β-amyloid clearance from the brain. A pivotal clinical trial with this approach studied active immunization of patients with AD against β-amyloid and the trial was stopped prematurely when some subjects developed...
Causes of cerebral microhemorrhages
Cerebral microhemorrhages on susceptibility weight magnetic resonance images are an important biomarker of cerebral arteriopathies. The iron in small foci of bleeding is released from hemoglobin and its magnetic properties induce a focal inhomogeneity in the magnetic field in MR images. This results in a small magnetic dipole artifact in...