Research projects


What causes cerebral microhemorrhages?
Susceptibility weight neuroimaging enables precise detection of tiny bleeds in the brain, 1-5 mm in diameter.  These are common in CAA, hypertension, infective endocarditis and aortic dissection.
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CAA in cerebral microvascular fragility
We are studying human brain with advanced 3D microscopy using our own optimized version of CLARITY to render brain tissue optically clear.  This allows us to observe the micro-vasculature of the brain in unpre-cedented detail.
Lysosome dysfunction in Alzheimer's disease and CAA
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Oxidative stress in CAA and Alzheimer's disease
An effective treatment for Alzheimer’s disease (AD) is urgently needed to stem the tide of the ongoing and growing epidemic of dementia.  An abnormal protein called β-amyloid is thought to be a major driver of memory loss in AD and many recent clinical trials have attempted to reduce the level of this protein in the brain, either by activating the immune system to clear it or inactivating enzymes that produce it.  None of these trials has been successful yet.  We are proposing to explore this problem in a different way – my colleagues and I discovered that neuronal axons around deposits of β-amyloid are swollen and filled with lysosomes, but these lysosomes are deficient in protein-degrading enzymes.  Because lysosomes are so important to protein homeostasis and this pathology is so dramatic, we hypothesize that these abnormal lysosomes contribute to the formation of β-amyloid plaques and if their function could be rescued they may be able to break down these plaques and improve brain function without immune activation or inactivating important enzymes. 
How changes in cellular management of oxidative stress contributes to neurodegeneration and vascular degeneration.  And the impact of diet, exercise, genetics and aging on this process.
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Retinal artery occlusion
.... and why it is important to neurological health.
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Recent data and publications

We will put recent full-text manuscripts here to share with our collaborators.  If you would like full-text access to any of our manuscripts which are not included here, contact us under the "Get Involved" tab.
Neuropsychological effects of CAA
2016, Curr Neurol Neurosci Reports
Cerebral Microhemorrhages and Meningeal Siderosis in Infective Endocarditis
2016, {cke_protected}{C}%3C!%2D%2D%20%2Freact-text%20%2D%2D%3ECerebrovascular Diseases 43(1-2):59-67.{cke_protected}{C}%3C!%2D%2D%20react-text%3A%2060%20%2D%2D%3E 
Stroke Risk and Risk Factors in Patients with Central Retinal Artery Occlusion 
2018, American Journal of Ophthalmology
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Trends in CRAO management
2017, Journal of Neurology
Oxidative markers in AD brain
2017, Free Radic Biol Med
Circulating Troponin I Level in Patients with Acute Ischemic Stroke
2018, Curr Neurol Neurosci Reports
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